Gut peptides before and following Roux-En-Y gastric bypass: A systematic review and meta-analysis

Simoneau, Mylène et McKay, Brad et Brooks, Emma et Doucet, Éric et Baillot, Aurélie (2022). Gut peptides before and following Roux-En-Y gastric bypass: A systematic review and meta-analysis. Obesity Reviews, 25 (5).

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Résumé

A systematic search was conducted in Medline Ovid, Embase, Scopus, and Cochrane Central Register of Controlled Trials up until March 2021 following PRISMA guidelines. Studies included evaluated ghrelin, GLP-1, PYY or appetite sensation via visual analogue scales (VASs) before and after Roux-en-Y gastric bypass (RYGB) in adults. A multilevel model with random effects for study and follow-up time points nested in study was fit to the data. The model included kcal consumption as a covariate and time points as moderators. Among the 2559 articles identified, k = 47 were included, among which k = 19 evaluated ghrelin, k = 40 GLP-1, k = 22 PYY, and k = 8 appetite sensation. Our results indicate that fasting ghrelin levels are decreased 2 weeks post-RYGB (p = 0.005) but do not differ from baseline from 6 weeks to 1-year post-RYGB. Postprandial ghrelin and fasting GLP-1 levels were not different from pre-surgical values. Postprandial levels of GLP-1 increased significantly from 1 week (p < 0.001) to 2 years post-RYGB (p < 0.01) compared with pre-RYGB. Fasting PYY increased at 6 months (p = 0.034) and 1 year (p = 0.029) post-surgery; also, postprandial levels increased up to 1 year (p < 0.01). Insufficient data on appetite sensation were available to be meta-analyzed.

Type de document:	Article
Mots-clés libres:	Appetite; Ghrelin; Glucagon-like peptide-1; Meta-analysis; Peptide YY; Roux-en-Y gastric bypass; Systematic review
Départements et école, unités de recherche et services:	École interdisciplinaire de la santé
Date de dépôt:	27 août 2026 14:33
Dernière modification:	27 août 2026 14:33
URI:	https://di.uqo.ca/id/eprint/1999

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